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. 2023 Dec 11;21:906. doi: 10.1186/s12967-023-04770-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a Effect of omentin-1 on hepatocyte fat accumulation. b, c Effect of omentin-1 and FFA co-treatment on the mRNA expression and supernatant release of TNF-α in Huh7 cells with FFA. d–f Effect of omentin-1 treatment on the NF-κB, ERK, and JNK mRNA expression in Huh7 cells with FFA. g, h Effect of omentin-1 treatment on ER stress markers BiP and CHOP in Huh7 cells with FFA. i–l Effects of omentin-1 treatment on the production of ROS in Huh7 with FFA. Values presented are the mean ± SD of at least three biological replicates. GSH and GSSG contents were normalized by the total proteins present in the cell lysates (µg) assessed using BCA. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

Fig. 3 — a Effect of omentin-1 on hepatocyte fat accumulation. b, c Effect of omentin-1 and FFA co-treatment on the mRNA expression and supernatant release of TNF-α in Huh7 cells with FFA. d–f Effect of omentin-1 treatment on the NF-κB, ERK, and JNK mRNA expression in Huh7 cells with FFA. g, h Effect of omentin-1 treatment on ER stress markers BiP and CHOP in Huh7 cells with FFA. i–l Effects of omentin-1 treatment on the production of ROS in Huh7 with FFA. Values presented are the mean ± SD of at least three biological replicates. GSH and GSSG contents were normalized by the total proteins present in the cell lysates (µg) assessed using BCA. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001