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. 2023 Dec 12;21:491. doi: 10.1186/s12916-023-03177-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig 6 — Disruption of rs4558409 promotes neural development and vesicle trafficking. A, B Effects of rs4558409-KO (KO) on PLLP RNA (A) and protein (B) expression levels in SK-N-SH cells. **p< 0.01 and ****p < 0.0001 from two-tailed Student’s t test. The relative intensity of binding as determined via Western blot analysis is shown underneath each band. C rs4558409-KO promoted neural development of SK-N-SH cells without or with ATRA treatment. The scale bar represents 100 μm. D Neurite-like length of the wild-type (WT, orange) or rs4558409-KO (KO, red) SK-N-SH cells without (solid) or with ATRA treatment (hatched). ****p<0.0001 from one-way ANOVA with Tukey’s multiple comparisons test. E FM4-64 imaging analysis of the wild-type (WT, orange) or rs4558409-KO (KO, red) SK-N-SH cells. ****p< 0.0001 obtained from two-way ANOVA. F Functional enrichment analysis of rs4854158-KO-induced DEGs in SK-N-SH cells