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. Author manuscript; available in PMC: 2023 Dec 12.
Published in final edited form as: Nat Rev Genet. 2022 Nov 23;24(5):276–294. doi: 10.1038/s41576-022-00550-0

Fig. 6 |. A network view of the nexus.

Fig. 6 |

Shown is a compilation of converging RNA-binding protein (RBP)–effector interactions that have been characterized at both the molecular and functional levels. Note that several RBPs (blue shapes) connect (black lines) to more than one effector (grey shapes) and that there also exist RBP-independent interactions between different effectors (grey lines). Solid and dashed lines denote direct and indirect (adaptor-mediated) protein–protein interactions (PPIs), respectively. The green line that connects FUS and the spliceosome represents an RBP–RNA interaction. Purple lines represent disease-associated or therapeutically targeted interactions (Table 2). The purple circle around survival motor neuron protein (SMN) indicates spinal muscular atrophy (SMA)-linked mutations of SMN that weaken its affinity for multiple RBPs. Only mammalian RBPs are shown. Motor proteins (motors; KIF11, KIF3C, KIF5A, KIF3AB) and translation initiation factors (eIFs; eIF4E, eIF4E2 (4EHP), eIF4G) have been grouped together and are shown as a single effector. Non-converging PPIs discussed in the text, TDP43–Kapβ2/a1 and MATR3–TREX, are omitted. CPEB, cytoplasmic polyadenylation element binding protein; MKRN1, makorin 1; PABPC, cytoplasmic poly(A)-binding protein; STAU, Staufen.