Table 5.

Multivariable analysis – sensitivity analyses.

	Unadjusted HR (95% CI)	p-Value	Adjusted HR* (95% CI)	p-Value
Primary endpoint: occurrence of catheter-related infection
⩾70 years vs <70 years (reference), excluding short-term dialysis †	0.88 (0.69–1.12)	0.31	0.78 (0.60–1.00)	0.05
⩾70 years vs <70 years (reference), excluding femoral CVC	0.88 (0.68–1.13)	0.30	0.82 (0.63–1.06)	0.13
⩾70 years vs <70 years (reference), chronic dialysis only ‡	0.77 (0.53–1.12)	0.17	0.82 (0.56–1.19)	0.29
Secondary endpoint: occurrence of catheter malfunction
⩾70 years vs <70 years (reference), excluding short-term dialysis †	0.92 (0.73–1.14)	0.44	0.92 (0.73–1.15)	0.46
⩾70 years vs <70 years (reference), excluding femoral CVC	0.99 (0.78–1.26)	0.95	1.02 (0.80–1.31)	0.85
⩾70 years vs <70 years (reference), chronic dialysis only ‡	0.94 (0.62–1.41)	0.75	0.86 (0.58–1.28)	0.46
Secondary endpoint: removal due to catheter-related infection or malfunction
⩾70 years vs <70 years (reference), excluding short-term dialysis †	0.93 (0.79–1.10)	0.43	0.92 (0.78–1.09)	0.34
⩾70 years vs <70 years (reference), excluding femoral CVC	0.96 (0.80–1.15)	0.64	0.98 (0.82–1.18)	0.85
⩾70 years vs <70 years (reference), chronic dialysis only ‡	0.78 (0.58–1.07)	0.12	0.84 (0.63–1.11)	0.22

CI: confidence interval; CVC: central venous catheter; HR: hazard ratio; (N)T: (non)-tunnelled.

^*Adjusted for age, sex, history of diabetes, cerebrovascular disease and peripheral vascular disease, type of CVC (i.e. precurved NTCVC, straight NTCVC or TCVC), use of immunosuppressive drugs (primary endpoint and removal due to infection/malfunction only) and use of antiplatelet drugs or anticoagulants (secondary endpoints only).

^†Defined as less than three dialysis sessions.

^‡Defined as more than 90 days of dialysis.