Table V.
Intra-Day Precision, Inter-Day Precision, Accuracy, Recovery, ME, IS-Corrected ME, Freeze–Thaw Stability and Autosampler Stability
| Analyte, cons. (nM) | Intra-day precision (%CV) | Inter-day precision (%CV) | Accuracy (%bias) | Recovery (%CV) | ME (%CV) | IS-corrected ME (%CV) | Freeze–thaw stability (%bias) | Autosampler stability (%bias) | |
|---|---|---|---|---|---|---|---|---|---|
| 1 day | 3 days | ||||||||
| Metodesnitazene | |||||||||
| 40 | 13 | 9 | 0 | 4 | 22 | ||||
| 8 | 1 | 9 | −1 | 95 (4) | 135 (2) | 151 (10) | 16 | −8 | 0 |
| 0.8 | 10 | 7 | 4 | 91 (5) | 211 (17) | 179 (10) | −2 | 3 | 2 |
| Flunitazene | |||||||||
| 40 | 9 | 5 | −3 | −1 | 4 | ||||
| 8 | 2 | 7 | −1 | 81 (9) | 93 (6) | 101 (5) | 18 | −2 | −2 |
| 0.8 | 5 | 5 | 4 | 86 (8) | 103 (3) | 89 (10) | 5 | −0 | 5 |
| Metonitazene | |||||||||
| 40 | 13 | 10 | 0 | 3 | 19 | ||||
| 8 | 4 | 7 | −3 | 94 (4) | 103 (6) | 111 (9) | 12 | −5 | −2 |
| 0.8 | 6 | 5 | 5 | 95 (9) | 115 (3) | 99 (9) | 2 | 2 | 2 |
| Etodesnitazene | |||||||||
| 40 | 13 | 9 | 1 | 4 | 31 | ||||
| 8 | 5 | 8 | −3 | 97 (5) | 163 (1) | 186 (10) | 25 | −21 | −13 |
| 0.8 | 9 | 6 | 5 | 98 (5) | 233 (17) | 197 (8) | −2 | 6 | 10 |
| Etonitazepyne | |||||||||
| 40 | 8 | 5 | 3 | 4 | 13 | ||||
| 8 | 3 | 5 | 0 | 99 (3) | 119 (8) | 131 (3) | 6 | −6 | 1 |
| 0.8 | 7 | 4 | 3 | 102 (3) | 152 (18) | 130 (11) | 0 | 1 | 3 |
| Clonitazene | |||||||||
| 40 | 3 | 3 | 1 | 1 | 4 | ||||
| 8 | 4 | 3 | −1 | 82 (10) | 100 (13) | 109 (109) | 5 | −4 | −1 |
| 0.8 | 2 | 4 | −2 | 87 (7) | 110 (14) | 95 (9) | −2 | −2 | 4 |
| 0.3 | 3 | 6 | −3 | 11 | 13 | ||||
| Etonitazene | |||||||||
| 40 | 2 | 2 | 1 | 0 | 8 | ||||
| 8 | 6 | 6 | −3 | 93 (8) | 106 (12) | 115 (4) | 5 | −7 | −2 |
| 0.8 | 10 | 7 | 6 | 91 (16) | 118 (12) | 102 (16) | −2 | 3 | 3 |
| Isotonitazene | |||||||||
| 40 | 6 | 5 | 2 | 3 | 16 | ||||
| 8 | 10 | 7 | 0 | 93 (3) | 102 (9) | 110 (2) | 8 | −11 | 3 |
| 0.8 | 12 | 6 | 6 | 91 (13) | 125 (19) | 108 (10) | 13 | 5 | 4 |
| Protonitazene | |||||||||
| 40 | 4 | 6 | 5 | 8 | 2 | ||||
| 8 | 15 | 13 | −3 | 81 (14) | 112 (24) | 122 (16) | 6 | −16 | −10 |
| 0.8 | 10 | 11 | 0 | 94 (6) | 137 (28) | 116 (20) | 22 | −7 | −5 |
| 0.3 | 16 | 13 | 0 | −4 | 3 | ||||