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Bacterial load and cytokine levels in the lungs and blood of T. pyogenes -infected mice. (A) Bacterial load in the lung (CFU/g of tissue) and blood (CFU/mL). ELISA was used to detect the levels of (B) IL-1β, (C) IL-6, (D) TNF-α, (E) IFN-γ, and (F) IL-10 in serum samples. Data are shown as the mean ± SD of the independent experiments; *P < 0.05, **P < 0.01, and ***P < 0.001.
