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The SNP rs10838543 CC genotype in TRIM22 inhibits HBV replication (A–C) HBsAg, HBeAg, and HBV DNA in the culture supernatants and preS1 mRNA (D) of HepAD38 cells stably expressing TRIM22 or control vector. (E and F) Levels of indicated cytokines in the culture supernatants of HepAD38 cells stably expressing TRIM22 or control vector. Data from a representative experiment of two or three independent replicates are shown. Unpaired Student’s t-test, *P < 0.05, **P < 0.01, ***P < 0.001.
