Fig 1.
The amino acid 17 in QRDR of GyrA contributes to intrinsic susceptibility of FQs in mycobacteria. (A) Alignment of the peptide sequences of the QRDR of GyrA from mycobacterial species and E. coli. (B and C) Drug susceptibility of different M. abscessus strains to MOX and levofloxacin. Tenfold serial dilutions of M. abscessus strains grown to OD600 of 0.7 were spotted on Middlebrook 7H10 containing indicated concentrations of antibiotics. Plates were incubated for 3 days. Representative data from three independent experiments are shown.