TABLE 1.

Stability of phage preparations for chronic rhinosinusitis, musculoskeletal infections, and sepsis

Indication (therapeutic threshold) Syringe Diluent	Phage	Day 1 vs day 5			Day 1 vs day 7
		Mean Δ (log PFU/mL)	P value	95% CI	Mean Δ (log PFU/mL)	P value	95% CI
Chronic rhinosinusitis (1 × 109 PFU/mL) 1 mL polycarbonate NaCl 0.9%	ISP	0.111	0.2641	[−0.32 to 0.09]	0.107	0.1335	[−0.25 to 0.04]
	14-1	0.003	0.8438	[−0.48 to 0.12]	0.011	0.9455	[−0.44 to 0.42]
	PT07	0.528	<0.0001 a	[−0.64 to −0.42]	0.760	<0.0001 a	[−0.92 to −0.60]
	PNM	0.088	0.4375	[−0.22 to 0.48]	0.190	0.2089	[−0.53 to 0.15]
	Phages combined	0.070	0.0595	[−0.50 to 0.10]	0.136	0.0852	[−0.40 to 0.05]
Musculoskeletal infections (1 × 107 PFU/mL) 20 mL polypropylene NaCl 0.9%	ISP	0.786	0.0039 a	[−1.16 to −0.41]	0.818	0.0043 a	[−1.22 to 0.42]
	14-1	0.431	<0.0001 a	[−0.53 to −0.33]	0.251	0.0765	[−0.54 to 0.04]
	PT07	0.197	0.056	[−0.01 to 0.40]	0.164	0.6318	[−0.77 to 0.44]
	PNM	0.465	0.0074 a	[−0.75 to −0.18]	0.543	0.0012 a	[−0.76 to −0.32]
	Phages combined	0.240	0.0101 a	[−0.43 to −0.05]	0.360	<0.0001 a	[−0.51 to −0.21]
Sepsis (1 × 108 PFU/mL) 50 mL polypropylene NaCl 0.9%	ISP	0.157	0.0051 a	[−0.24 to −0.07]	0.241	0.0210 a	[−0.43 to −0.05]
	14-1	0.055	0.9127	[−0.46 to 0.57]	0.233	0.0356 a	[−0.44 to −0.02]
	PT07	0.062	0.8321	[−0.33 to 0.45]	0.167	0.1019	[−0.05 to 0.38]
	PNM	0.180	0.0639	[−0.02 to 0.37]	0.210	0.0070 a	[0.083 to 0.34]
	Phages combined	0.008	0.9903	[−0.15 to 0.16]	0.065	0.5244	[−0.09 to 0.22]

^a P value < 0.05 is considered statistically significant, CI = confidence interval, Δ = change. PFU: plaque-forming units.