TABLE 2.

Stability of phage preparations for pulmonary infections in cystic fibrosis and bronchiectasis patients

Indication (therapeutic threshold) Syringe Diluent	Phage	Day 1 vs day 7			Day 1 vs day 14			Day 1 vs day 21
		Mean Δ (log PFU/mL)	P value	95% CI	Mean Δ (log PFU/mL)	P value	95% CI	Mean Δ (log PFU/mL)	P value	95% CI
Pulmonary infections (1 × 108 PFU/mL) 4 mL polypropylene NaCl 0.9%	ISP	0.373	0.2297	[−0.99 to 0.24]	0.638	0.0208 a	[−1.15 to −0.12]	0.646	0.6301	[−12.46 to 11.17]
	14-1	0.073	0.9729	[−1.01 to 0.87]	0.725	0.0814	[−1.60 to 0.15]	0.748	0.4267	[−7.72 to 6.23]
	PT07	0.525	0.0103 a	[−0.86 to 0.020]	0.618	0.0034 a	[−0.91 to −0.33]	0.863	0.1732	[−3.89 to 2.17]
	PNM	0.200	0.2593	[−0.71 to 0.31]	1.029	0.0064 a	[−1.52 to −0.54]	1.500	0.0847	[−4.05 to 1.05]
	Phages combined	0.367	0.0024 a	[−0.62 to −0.11]	0.779	<0.0001 a	[−1.02 to −0.54]	0.996	<0.0001 a	[−1.31 to −0.68]

^a P value < 0.05 is considered statistically significant, CI = confidence interval, Δ = change. PFU: plaque-forming units.