TABLE 3.
Phage characteristics
| Phage | Phage classification (family, genus) | Phage morphology | Propagation strain | Genome accession # | Genome size (kb) | Phage receptor | Host range (% of clinical isolates) |
Refs |
|---|---|---|---|---|---|---|---|---|
| ISP | Herelleviridae, Kayvirus | Myovirus | S. aureus ATCC 6538 | NC_047720 NC_047720 | 138.3 | WTA a | 73% b | (3, 18) |
| 14-1 | Caudoviricetes, Pbunavirus | Myovirus | P. aeruginosa CN573 | NC_011703 | 66.1 | LPS | 25% c | (19) |
| PNM | Autographiviridae, Phikmvvirus | Podovirus | P. aeruginosa CN573 | OP292288 | 42.7 | Pili | ~27% c | (20) |
| PT07 | Caudoviricetes, Pakpunavirus | Myovirus | P. aeruginosa CN573 | OQ850183 | 94.7 | MexAB-OprM d | 17% c | (21) |
Staphylococcal Twort-like bacteriophages like ISP are known to have at least two receptor binding proteins: the glycosylated wall teichoic acids (WTAs) and the WTA backbone.
The host range was calculated based on clinical data from 92 S. aureus strains, collected between 2020-2023 at the Queen Astrid Military Hospital (unpublished data). Only lysis from within results are included.
The host range was calculated based on clinical data from 343 P. aeruginosa strains, collected between 2020-2023 at the Queen Astrid Military Hospital (unpublished data). Only lysis from within results are included.
The receptor for PT07 is not known, but sequence similarity to PAK-P1 like bacteriophages (98.26% identity to bacteriophage PaP1) suggests it might be the P. aeruginosa MexAB-OprM multidrug efflux pump.