FIG. 6.

Promiscuous viral infection and/or expression can confound reports of intrinsic regeneration. (A) In the preferred case, virus only transduces and becomes activated in Müller glia (pink) (left panel), and therefore neurogenesis from labeled Müller glia (red) is the exclusive source of labeled mature neurons (green) (right panel). (B) In the alternate case, virus may transduce and become active in several retinal cell types (pink), even if inefficiently (left panel), and labeled mature neurons (red) may be directly transduced rather than produced by neurogenesis (right panel).