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. Author manuscript; available in PMC: 2023 Dec 12.
Published in final edited form as: J Inherit Metab Dis. 2023 May;46(3):436–449. doi: 10.1002/jimd.12617

FIGURE 3.

FIGURE 3

SIRTIUN enzymes: compartmentalization and function. (A) Diagram demonstrating substrate preference and cellular compartment localization of each SIRT family member as well as established function of the mitochondrial SIRTs necessary for preservation of metabolic function.(B) SIRT3 regulated metabolic pathways. Green arrows indicate increased protein activity following modification by SIRT3. (C) SIRT4 regulated metabolic pathways. Green arrows indicate increased protein activity and red bars indicate reduced protein activity following modification by SIRT4. (D) SIRT5 regulated metabolic pathways. Green arrows indicate increased protein activity and red bars indicate reduced protein activity following modification by SIRT5.