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. 2023 Jul 28;72(12):2307–2320. doi: 10.1136/gutjnl-2022-329147

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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MS4A4A was highly expressed in tumour-associated macrophages and associated with a poor prognosis in patients with cancer. (A) Analysis of MS4A4A gene expression in various tumours using the pan-cancer single-cell sequencing data set from the TISCH database (http://tisch.comp-genomics.org/). (B) Representative images of immunofluorescence costaining for MS4A4A (red) with cell-type markers (green) in clinical human CRC tissue specimens. (C) IHC staining with MS4A4A-specific antibodies to detect MS4A4A⁺ cells infiltration in a human CRC tissue microarray (n=81). (D) Overall survival curves based on MS4A4A⁺ cells infiltration level using the Kaplan-Meier method. (E) The Kaplan-Meier Plotter online tool (https://kmplot.com/analysis/) was used to analyse the association between MS4A4A mRNA expression levels and overall survival in various tumour (including colon cancer, lung cancer, ovarian cancer, gastric cancer, breast cancer, bladder cancer, oesophageal cancer and thymoma). CRC, colorectal cancer; IHC, immunohistochemistry; mRNA, messenger RNA; TISCH, Tumour Immune Single-cell Hub.