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. 2023 May 16;25(6):662–673. doi: 10.4103/aja202315

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Copyright: © The Author(s)(2023)

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Candidate regulators of XIST. (a) Twenty candidate transcription regulators and their binding motifs within −3 kb of the transcriptional start site of the XIST gene. The score was calculated using the JASPAR dataset. (b) Heatmap showing the expression level of XIST and its regulators in OA and KS Sertoli cells. (c) A violin plot shows the expression level of XIST regulators predicted by the PROMO dataset in each cell cluster of OA and KS cells. (d) A violin plot shows the expression level of XIST regulators validated by previous studies in each cell cluster of OA and KS cells. XIST: X-inactive-specific transcript; SPGs: spermatogonia; SPCs: spermatocytes; SPT: spermatids; SCs: Sertoli cells; LCs: Leydig cells; PTMs: peritubular myoid cells; ECs: endothelial cells; VSMs: vascular smooth muscle cells; Mo&Mφ: monocyte and macrophage; OA: obstructive azoospermia; KS: Klinefelter syndrome; UMI: unique molecular identifier.