Table 5. Expression quantitative trait loci (eQTL) associated with worm burden.
A) 100kb analysis: Flanking regions of 100 kilobases on either side of candidate gene | ||||||
GENE | N | Chr | Significant SNP identifier | BP | Raw P | Bonferroni Adjusted P |
IL5 | 101 | 5 | rs201918473 | 131,821,658 | 8.02E-05 | 0.0081 |
IL5 | 101 | 5 | kgp11181534 | 131,822,055 | 8.02E-05 | 0.0081 |
IL5 | 101 | 5 | kgp7862224 | 131,822,072 | 8.02E-05 | 0.0081 |
IL5 | 101 | 5 | kgp6078763 | 131,819,126 | 0.00010 | 0.010 |
IL5 | 101 | 5 | rs13165038 | 131,813,350 | 0.00010 | 0.011 |
IL6 | 152 | 7 | rs114644824 | 22,867,134 | 0.00025 | 0.038 |
IL5 | 101 | 5 | kgp2459073 | 131,813,219 | 0.00049 | 0.049 |
IL5 | 101 | 5 | kgp888688 | 131,819,921 | 0.00049 | 0.049 |
B) 1Mb analysis: Flanking regions of 1 megabase on either side of candidate gene | ||||||
GENE | N | Chr | Significant SNP identifier | BP | Raw P | Bonferroni Adjusted P |
IL25 | 1262 | 14 | h3a_37_14_24685193_T_C | 24,685,193 | 1.30E-05 | 0.016 |
IFNG | 1353 | 12 | kgp3424793 | 69,349,042 | 1.63E-05 | 0.022 |
IL21 | 954 | 4 | kgp10917231 | 123,831,293 | 3.74E-05 | 0.036 |
IL21 | 954 | 4 | rs13106595 | 123,873,534 | 3.74E-05 | 0.036 |
IL5 | 997 | 5 | rs201918473 | 131,821,658 | 8.02E-05 | 0.080 |
IL5 | 997 | 5 | kgp11181534 | 131,822,055 | 8.02E-05 | 0.080 |
IL5 | 997 | 5 | kgp7862224 | 131,822,072 | 8.02E-05 | 0.080 |
N = number of SNP tested for association with gene RNA sequences
The number of individuals who had data analyzed were 38 infected and 20 uninfected children.
SigSNP = Significant SNP
Raw P = Raw p-value
Bonferroni adjusted P = p-values adjusted by Bonferroni correction (Raw P * N)