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. 2023 Nov 30;19(11):e1011043. doi: 10.1371/journal.pgen.1011043

Fig 4. Mesoscale properties of A3A and A3B in vitro and in the HAP1-TK-M9 system.

Fig 4

(A-B) Deamination kinetics of A3A and A3B using SDHB and NUP93 DNA hairpin substrates in comparison to corresponding linear controls made by scrambling the 5’ or 3’ portion of the stem, respectively. See text for full description and S13 Fig for a genome-wide analysis and S14 Fig for a gel-based confirmation of DNA oligonucleotide integrity. (C) Rainfall plots of genome-wide intermutation distances for APOBEC3 signature single base substitution mutations in representative granddaughter clones (C>T mutations are red, C>G black, other SBS gray). See S15 Fig for an additional analysis of dispersed versus clustered single base substitution mutations.