Fig 5. A composite origin of APOBEC3 signature mutations in breast cancer.

An unsupervised clustering analysis of similarity between the pentanucleotide SBS profiles from WGSs of the A3A, A3B, and control granddaughter clones described here versus those from primary breast tumor whole-genome sequencing data sets (ICGC, n = 784). The APOBEC3 mutation signature is represented by both enrichment score and SBS2+13 (red), HRD signature as SBS3 (blue), and ageing signature as SBS1 (gray).