TABLE 2.
Univariable and multivariable analyses of local recurrence in 891 patients with cT3–4 rectal cancer ≤8 cm from the anorectal junction who were treated with neoadjuvant radiotherapy (short course or chemoradiotherapy)
| Variable | No. | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | ||
| LLN of any size present No Yes |
607 284 |
1 2.414 |
1.556–3.744 | <0.001 | 1 1.787 |
1.130–2.827 | 0.013 |
| Sex Male Female |
581 310 |
1 0.953 |
0.600–1.515 | 0.839 | |||
| Age, y <55 55–75 ≥75 |
50 472 369 |
1 0.849 1.014 |
0.336–2.147 0.396–2.598 |
0.736 | |||
| Neoadjuvant radiotherapy 5 × 5 CRT |
338 553 |
1 1.496 |
0.922–2.428 | 0.103 | |||
| Clinical T stage T3a T3b T3c T3d T4a T4b |
174 287 221 56 53 100 |
1 1.474 2.138 2.637 5.913 4.460 |
0.645–3.367 0.941–4.854 0.915–7.601 2.378–14.704 1.907–10.430 |
<0.001 | 1 0.994 1.085 0.920 2.484 1.155 |
0.427–2.312 0.463–2.546 0.304–2.782 0.942–6.549 0.453–2.941 |
0.231 |
| Mesorectal clinical N stage N0 N1 N2 |
183 400 308 |
1 0.669 1.618 |
0.349–1.281 0.897–2.917 |
0.003 | 1 0.641 1.208 |
0.327–1.255 0.646–2.258 |
0.059 |
| mrEMVI Absent Present |
577 314 |
1 2.543 |
1.635–3.956 | <0.001 | 1 2.102 |
1.283–3.444 | 0.003 |
| Tumor deposits Absent Present |
748 143 |
1 2.569 |
1.592–4.146 | <0.001 | 1 1.676 |
0.986–2.850 | 0.056 |
| Surgerya Sphincter nonsparing Sphincter sparing |
340 551 |
1 0.508 |
0.328–0.789 | 0.003 | 1 0.580 |
0.358–0.940 | 0.027 |
| Margin status R0 R1 |
823 68 |
1 6.837 |
4.176–11.193 | <0.001 | 1 5.820 |
3.410–9.932 | <0.001 |
These patients were included in the analysis based on visibility on primary staging MRI, independent of size.
Boldface indicates statistically significant findings.
LLN = lateral lymph node; mrEMVI = MRI-identified extramural venous invasion.
a
Sphincter nonsparing includes abdominoperineal resections and proctocolectomy cases and sphincter sparing cases include (low) anterior resections and local excisions.