Table 3.
Demographic data and initial signs in patients with CBD–CBS, PSP–CBS and AD–CBS
| Feature | CBD–CBS (n = 16) | PSP–CBS (n = 14) | AD–CBS (n = 6) | P-value, OR [(95% CI); CBD–CBS versus PSP–CBS] | P-value, OR [(95% CI); CBD–CBS versus AD–CBS] | P-value, OR [(95% CI); PSP–CBS versus AD–CBS] |
|---|---|---|---|---|---|---|
| Age at onset, years | 63.5 ± 8.5 (45–79) | 67.8 ± 6.3 (59–79) | 69.5 ± 11.6 (55–86) | 0.132 (−9.95 to 1.38) | 0.196 (−3.36 to 15.36) | 0.670 (−10.02 to 6.59) |
| Age at death, years | 71.6 ± 8.7 (50–86) | 75.9 ± 5.9 (68–88) | 77.8 ± 12.0 (62–93) | 0.131 (−9.97 to 1.36) | 0.195 (−3.45 to 15.87) | 0.724 (−14.52 to 10.71) |
| Duration of disease, years | 8.4 ± 3.4 (4–17) | 8.6 ± 3.6 (4–18) | 8.5 ± 1.8 (7–11) | 0.873 (−2.81 to 2.40) | 0.966 (−2.98 to 3.10) | 0.928 (−3.12 to 3.41) |
| Gait disturbance | 13/15 (87) | 10/14 (71) | 5/6 (83) | 0.390, 2.60 (0.39–17.16) | 1.000, 1.30 (0.10–17.73) | 1.000,0.50 (0.04–5.74) |
| Slow gait | 8/10 (80) | 4/11 (36) | 2/3 (67) | 0.081, 7.00 (0.97–50.57) | 1.000, 2.00 (0.11–34.82) | 0.539, 0.29 (0.02–4.24) |
| Unstable gait | 7/11 (64) | 7/12 (58) | 2/5 (40) | 1.000, 1.25 (0.23–6.71) | 0.596, 2.63 (0.30–22.00) | 0.620, 2.10 (0.25–17.59) |
| Frozen gait | 7/11 (64) | 0/9 (0) | 0/3 (0) | 0.005*, 31.67 (1.46–685.34) | 0.192, 11.67 (0.48–282.06) | 1.000, 0.37 (0.01–22.39) |
| Short steps gait | 7/11 (64) | 1/10 (10) | 3/5 (60) | 0.024*, 15.75 (1.42–174.25) | 1.000, 1.17 (0.13–10.22) | 0.077, 0.67 (0.00–1.14) |
| Bradykinesia | 8/11 (73) | 8/12 (67) | 3/4 (75) | 1.000, 1.33 (0.22–7.98) | 1.000, 0.89 (0.06–12.25) | 1.000,0.67 (0.05–8.64) |
| Clumsy limbs | 8/13 (62) | 10/14 (71) | 4/6 (67) | 0.695, 0.64 (0.13–3.20) | 1.000, 0.80 (0.10–6.10) | 1.000, 1.25 (0.16–9.77) |
| Falls | 5/11 (45) | 5/13 (38) | 1/5 (20) | 1.000, 1.33 (0.26–6.81) | 0.588, 3.33 (0.28–40.29) | 0.615, 2.50 (0.21–29.26) |
| Amnesia | 4/13 (31) | 4/14 (29) | 3/6 (50) | 1.000, 1.11 (0.21–5.80) | 0.617, 0.44 (0.06–3.24) | 0.613, 0.40 (0.06–2.89) |
| Tremor | 6/15 (40) | 0/14 (0) | 2/6 (33) | 0.017*, 19.84 (0.00–394.8) | 1.000, 1.33 (0.18–9.73) | 0.079, 0.06 (0.00–1.51) |
| Speech disturbance | 5/12 (42) | 7/13 (54) | 2/5 (40) | 0.695, 0.61 (0.13–2.98) | 1.000, 1.07 (0.13–8.98) | 1.000, 1.75 (0.22–14.22) |
| Dysarthria | 3/10 (30) | 6/13 (46) | 0/5 (0) | 0.669, 0.50 (0.09–2.84) | 0.506, 5.13 (0.22–121.11) | 0.114, 9.53 (0.44–207.38) |
| Aphasia | 1/10 (10) | 3/13 (23) | 0/4 (0) | 0.604, 0.37 (0.034.23) | 1.000, 1.42 (0.05–42.22) | 0.541, 3.00 (0.13–70.88) |
| Personality change | 3/11 (27) | 1/12 (8) | 1/4 (25) | 0.317, 4.13 (0.36–47.31) | 1.000, 1.13 (0.08–15.51) | 0.450, 0.27 (0.01–5.77) |
| Lack of insight | 3/12 (25) | 1/10 (10) | 1/3 (33) | 0.594, 3.00 (0.26–34.58) | 1.000, 0.67 (0.04–10.25) | 0.423, 0.22 (0.01–5.28) |
| Apraxia | 3/11 (27) | 6/12 (50) | 4/5 (80) | 0.400, 0.38 (0.07–2.14) | 0.106, 0.09 (0.01–1.21) | 0.338, 0.25 (002–2.94) |
| Behavioural change | 1/13 (8) | 1/12 (8) | 0/5 (0) | 1.000, 0.92 (0.05–16.50) | 1.000, 1.32 (0.05–37.78) | 1.000, 1.43 (0.05–41.23) |
| Irritability | 1/13 (8) | 2/11 (18) | 1/4 (25) | 0.576, 0.38 (0.03–4.81) | 0.427, 0.25 (0.01–5.26) | 1.000, 0.67 (0.04–10.25) |
Data are presented as mean ± SD (range) or n (%). Bold number indicates statistical significance. AD, Alzheimer's disease; CBD, corticobasal degeneration; CBS, corticobasal syndrome; PSP, progressive supranuclear palsy [*P < 0.05 (t-test or Fisher’s exact test)]; OR, odds ratio; 95% CI, 95% confidence interval.