Figure 4.

PCSK9 Inhibition Improves Age-Related Cardiovascular Dysfunction

(A) Representative echocardiography recordings and echocardiography results. (B) Strain analysis. (C) PV analysis with representative recordings. ∗P < 0.05 vs young; #P < 0.05 vs aging. One-way analysis of variance with Tukey’s post hoc test. Scattered dot plots show mean ± SEM. AW = anterior wall; CSr = circumferential strain rate; CSrE = circumferential strain rate E-wave; d = diastole; dP/dt = maximal rate of left ventricular pressure rise; EDV = end-diastolic volume; E/A = E-wave to A-wave ratio; GCS = global circumferential strain; ID = internal diameter; PW = posterior wall; s = systole; other abbreviations as in Figure 1.