Figure 5.

PCSK9 Inhibition Attenuates Cardiac Hypertrophy

(A) Hematoxylin and eosin histology and (B) cardiomyocyte diameter. (C) Heatmap of hypertrophy- and contractility-related genes from transcriptomic analysis. (D) Gene expression levels of Myh-7 and Myh-6 (alpha and beta myosin heavy chain [MHC], respectively). (E) Serum B-type natriuretic peptide (BNP) levels. ∗P < 0.05 vs young; #P < 0.05 vs aging. One-way analysis of variance with Tukey’s post hoc test. Scattered dot plots show mean ± SEM. FPKM = fragments per kilobase of transcript per Million mapped reads; mRNA = messenger RNA; PCSK9 = proprotein convertase subtilisin/kexin type 9.