Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 4;30(12):1958–1969. doi: 10.1038/s41594-023-01159-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — Real-time PCR of AR, KLK2, KLK3, FKBP5, NKX3.1, and ALAS1 transcript normalized to SDHA harvested from LNCaP tumors (a), and AR, AR-V7, CCNA2, UBE2C, B4GALT1 and ALAS1 transcript normalized to SDHA harvested from LNCaP95-D3 tumors (b). Both enzalutamide and 1ae show on target activity and do not affect expression of housekeeping gene ALAS1 in LNCaP xenografts. Conversely only 1ae is capable of repressing AR-V7 induced genes, or de-repressing AR-V7 repressed gene B4GALT1. Error bars represent s.e.m. of n = 3 samples per treatment arm.

Source data