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. 2023 Dec 12;13:22085. doi: 10.1038/s41598-023-49450-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of CD38 NADase with anti-CD38 antibody ameliorated skin fibrosis. (A) Schematic of experimental design. C57/BL6 mice were pretreated with i.p. Ab68 or Ab69, followed by a 14-day course of daily bleomycin (BLM) subcutaneous injections alone, or combined with Ab68 or Ab69 (7–8 mice/group). Mice were sacrificed at day 21. (B) Schematic of Ab68 targeting CD38 NADase. Ab68 and Ab69 are heavy-chain antibodies with human VH domains and a silenced mouse IgG2a. Both antibodies bind mouse CD38, but only Ab68 inhibits the NAD⁺ hydrolase function of CD38. (C) Body weight. Each dot represents the result from a single mouse. (D) Lesional skin, trichrome stain, representative images, left panels (bar scale = 100 μm). Quantitation of dermis thickness and dermal white adipose tissue (dWAT). (E) Skin collagen content. (F) Gene expression in skin measured by qPCR. Results are means ± SEM from an experiment representative of two independent experiments; each dot represents the mean of triplicate determinations from each mouse.