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Schematic representation of the L-arginine/dimethylarginine/nitric oxide (NO) pathway. L-arginine can be converted to NO and L-citrulline via NO synthase, or to L-ornithine via arginase. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are released from methylated proteins. ADMA directly inhibits NO synthase; ADMA and SDMA interfere with cellular L-arginine uptake.
