TABLE 4.
Correlations of biomarkers with physiological responses to hypoxia and acute mountain sickness in individuals without HAPE susceptibility (study A).
| Biomarker | Hb | PO2alv | AaDO2 | SpO2 | AMS-C | LLS |
|---|---|---|---|---|---|---|
| ADMA | −0.05/0.471 | −0.158/0.015 | −0.171/0.008 | −0.050/0.427 | 0.016/0.811 | 0.077/0.235 |
| SDMA | 0.026/0.694 | −0.233/<0.001 | −0.121/0.060 | −0.29/<0.001 | 0.131/0.044 | 0.252/<0.001 |
| L-Arginine | −0.060/0.326 | −0.013/0.841 | −0.149/0.02 | 0.129/0.046 | −0.060/0.371 | −0.070/0.264 |
| L-Citrulline | −0.010/0.837 | 0.202/0.002 | 0.002/0.719 | 0.199/0.002 | −0.167/0.010 | −0.185/0.004 |
| L-Ornithine | 0.201/0.002 | 0.192/0.003 | −0.025/0.698 | 0.292/<0.001 | −0.246/<0.001 | −0.332/<0.001 |
| Arg/ADMA Ratio | −0.006/0.929 | 0.110/0.090 | −0.040/0.537 | 0.180/0.005 | −0.101/0.119 | −0.157/0.015 |
| Cit/Arg Ratio | 0.030/0.645 | 0.183/0.005 | 0.162/0.012 | 0.070/0.264 | −0.081/0.212 | −0.098/0.132 |
| Orn/Arg Ratio | 0.207/0.001 | 0.150/0.021 | 0.086/0.187 | 0.129/0.047 | −0.131/0.044 | −0.190/0.003 |
Values shown are Pearson correlation coefficients/p values. *values for AMS, indicate statistical significance comparing plasma concentrations of the respective biomarkers in study participants with and without acute mountain sickness. Abbreviations: AaDO2, alveolar-to-arterial difference in partial oxygen pressure ADMA, asymmetric dimethylarginine; AMS, acute mountain sickness; AMS-C, acute mountain sickness-cerebral score; Cit/Arg ratio, L-citrulline/L-arginine ratio; Hb, blood hemoglobin concentration; LLS, lake louise score; Orn/Arg ratio, L-ornithine/L-arginine ratio; PO2alv, partial oxygen pressure in alveolar air; SDMA, symmetric dimethylarginine; SpO2, blood oxygen saturation. Bold values are the significant p values.