Skip to main content
. 2023 Nov 29;14:1297636. doi: 10.3389/fphys.2023.1297636

TABLE 5.

Correlations of biomarkers with physiological responses to hypoxia and acute mountain sickness in individuals with HAPE susceptibility (study B).

Biomarker Hb SaO2 PO2art SpO2 AMS-C LLS
ADMA 0.065/0.673 0.040/0.794 0.036/0.817 −0.012/0.924 −0.167/0.168 −0.195/0.109
SDMA 0.085/0.578 −0.132/0.387 0.055/0.718 −0.198/0.105 −0.074/0.545 −0.009/0.936
L-Arginine −0.249/0.990 0.228/0.133 0.080/0.601 0.288/0.017 −0.086/0.477 −0.236/0.050
L-Citrulline −0.334/0.025 0.271/0.072 0.318/0.033 0.122/0.323 0.045/0.712 −0.023/0.853
L-Ornithine −0.376/0.011 0.525/<0.001 0.377/0.011 0.483/<0.001 −0.213/0.070 −0.329/0.006
Arg/ADMA Ratio −0.302/0.044 0.183/0.229 0.486/<0.001 0.219/0.072 0.070/0.566 −0.035/0.774
Cit/Arg Ratio −0.149/0.328 0.086/0.574 0.436/0.003 −0.064/0.605 0.115/0.344 0.132/0.281
Orn/Arg Ratio −0.199/0.190 0.449/0.002 −0.172/0.258 0.368/0.002 −0.193/0.110 −0.210/0.083

Values shown are Pearson correlation coefficients/p values. *values for AMS, indicate statistical significance comparing plasma concentrations of the respective biomarkers in study participants with and without acute mountain sickness. Abbreviations: ADMA, asymmetric dimethylarginine; AMS, acute mountain sickness; AMS-C, acute mountain sickness-cerebral score; Cit/Arg ratio, L-citrulline/L-arginine ratio; Hb, blood hemoglobin concentration; LLS, lake louise score; Orn/Arg ratio, L-ornithine/L-arginine ratio; PO2art, partial oxygen pressure in arterial blood; SDMA, symmetric dimethylarginine; SaO2, arterial oxygen saturation in arterial blood gas analysis; SpO2, blood oxygen saturation in pulse oxymetry. Bold values are the significant p values.

HHS Vulnerability Disclosure