Table 1.

Scheduled Classes of Controlled Substances by the Controlled Substances Act of 1970

Schedule	Description	Example Substances
I	High abuse potential No accepted medical use	Heroin, LSD, MDMA, mescaline, psilocybin, marijuana/cannabis, cannabinoids, and peyote
II	High abuse potential Accepted medical use	Amphetamine, barbiturates, cocaine, fentanyl, methadone, and morphine
III	Medium abuse potential Accepted medical use	Ketamine, anabolic steroids, and buprenorphine
IV	Moderate abuse potential Accepted medical use	Benzodiazepines, tramadol, and carisoprodol
V	Lowest abuse potential Accepted medical use	Pregabalin, lacosamide, cannabis-derived pharmaceutical formulation (ie, Epidiolex)a

Notes: ^aOther cannabidiol formulations remain Schedule I except for those derived from hemp, which were unscheduled after passage of the Agricultural Improvement Act of 2018 but are still regulated by the US Food and Drug Administration.

Abbreviations: LSD, lysergic acid diethylamide; MDMA, methylenedioxymethamphetamine.