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. 2023 Nov 29;14:1320271. doi: 10.3389/fimmu.2023.1320271

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Copyright © 2023 Quan and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglia-mediated microenvironment remodeling and neural regeneration in hypoxic ischemic brain injury. In hypoxic-ischemic brain injury, the CNS sustains significant damage, resulting in the apoptosis and necrosis of numerous neurons and glial cells. Microglia, which act as protectors of the niche, play a crucial role in glia scar formation, microenvironment remodeling, and supporting the processes of neurogenesis and remyelination. The orange cytokines represent those secreted by microglia, and the purple cytokines represent those secreted by neurons. This figure was created by Adobe Illustrator software.