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. 2023 Nov 3;299(12):105418. doi: 10.1016/j.jbc.2023.105418

Figure 3.

Figure 3

MARK3 and STK10 knockdown effects on target proteins and cell growth.A, representative Western blots of MARK3, STK10, and respective downstream targets in knockdown cells. B, effects of siRNA-mediated knockdown of MARK3 or STK10 on MP38 and OMM1.3 cell growth were analyzed using the IncuCyte Live Cell Analysis Imaging System by measuring % plate coverage (n = 3). ∗p < 0.05 as determined by t test, and error bars are ± SEM. C, annexin-V staining (%) following MARK3 or STK10 knockdown in MP38 or OMM1.3 (n = 3). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 as determined by t test, and error bars are ± SEM. D, analysis of TCGA data for uveal melanoma patient disease-specific survival according to MARK3 and STK10 expression, above or below median RNA expression. Log-rank test was used to determine the significance of disease-specific survival.