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. 2023 Dec 12;21:909. doi: 10.1186/s12967-023-04616-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — SPOCK1 is associated with adverse clinical outcomes. A–H Prognostic value of SPOCK1 was assessed in the combined cohort and seven independent cohorts. I Heat map of the distribution of SPOCK1 with clinicopathological features. J Differential expression of SPOCK1 in normal and tumor tissues. K Differential expression of SPOCK1 between normal tissues and paired tumor tissues. L Differential expression of SPOCK1 in normal and tumor tissues. L GSEA analysis showing the activation profile of biological pathways in the high SPOCK1 group. (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance.)