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. 2023 Dec 12;21:909. doi: 10.1186/s12967-023-04616-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Role of SPOCK1 in the tumor microenvironment. A Heatmap of the distribution of 29 TME associated signatures with SPOCK1 expression values. B Scatter plot of the correlation between 4 TME scores and SPOCK1 expression values. C Histogram of correlation between SPOCK1 and 5 immune features and chord plot of correlation with TGF-β1 (TGFB1), TGF-β2 (TGFB2), and TGF-β3 (TGFB3) (spearman test). D Distribution of SPOCK1 expression in TME subtypes defined by Bagaev et al. E Correlation between SPOCK1 and CD274 (mRNA level) and PD- L1 (protein level, from TCPA database) correlation scatter plots. (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance.)