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Hot pack inhibited the up-regulation of NGF in the plantar skin and gastrocnemius muscle. NGF protein levels of the a plantar skin and b gastrocnemius muscle in the PI + hot pack group were significantly lower than the PI and the PI + sham group. No significant difference was observed between the PI and the PI + sham group. This elevated NGF level was suppressed by hot pack treatment. *p < 0.05, **p < 0.01 and ***p < 0.001 vs each other
