Table 9.
Phase variables
| Phase variable | Definition | ENDO | EPI |
|---|---|---|---|
| x r | Coefficient of open probability of the potassium channels for ikr | 0.51E−4 | 1.61E−4 |
| x s | Coefficient of open probability of the potassium channels for iks | 0.0659 | 0.0598 |
| r | Potassium channel activation coefficient for ito | 1.78E−8 | 1.80E−8 |
| s | Potassium channel inactivation coefficient for ito | 0.995 | 0.996 |
| m | Sodium channel activation coefficient | 0.0015 | 0.0016 |
| h | Sodium channel inactivation coefficient | 0.9948 | 0.9948 |
| d | L-channel activation coefficient | 2.2E−8 | 2.2E−8 |
| f | L-channel inactivation coefficient | 0.9999 | 0.9999 |
| f 2,ds | Degree of activation of the L-channels in DS | 0.9983 | 0.9980 |
| [Na+]i (mM) | Intracellular Na+ concentration | 4.6423 | 4.9982 |
| [K+]i (mM) | Intracellular K+ concentration | 138.0930 | 137.7124 |
| [K+]o (mM) | Extracellular K+ concentration | 3.9997 | 4.0019 |
| V (mV) | Membrane potential | −93.208 | −93.142 |
| FrAct | Fraction of activated channels | 0.00056 | 0.00205 |
| FrProd | Fraction of inactivated channels | 0.22573 | 0.30025 |
| [Ca2+]up (mM) | Ca2+ concentration in longitudinal reticulum | 1.38 | 1.50 |
| [Ca2+]rel (mM) | Ca2+ concentration in terminal cisterns | 1.37 | 1.49 |
| [Ca2+]i (mM) | Cytosolic Ca2+ concentration | 9.2E−6 | 9.5E−6 |
| [Ca2+]ds (mM) | DS Ca2+ concentration | 1.6E−6 | 2.0E−6 |
| [CaTnC] (mM) | CaTnC concentration | 2.3E−4 | 2.3E−4 |
| [B 1] (mM) | B1 buffer concentration | 4.0E−4 | 4.1E−4 |
| [B 2] (mM) | B2 buffer concentration | 9.0E−4 | 7.2E−4 |
| l 1 (μm) | Deformation of CE relative to the slack length | 0.2139 | 0.2262 |
| l (μm) | Deformation of PE relative to the slack length | 0.2139 | 0.2262 |
| l ex (μm) | Deformation of XSE relative to the slack length | 0.0436 | 0.0313 |
| v (μm/s) | Sarcomere shortening velocity | 6.7E−6 | 0.38E−6 |
| N | Fraction of force-generating Xbs | 3.3E−7 | 0.52E−7 |