Table 1.
The number and IOD of c-Fos-positive neurons in the forebrain in rats under continuous stress (n = 5)
| Group 0 | Group 30 | Group 60 | Group 120 | Group 180 | |
|---|---|---|---|---|---|
| Midline cortical areas | |||||
| mPFC | 0.95 ± 0.20a | 2.36 ± 0.26b | 4.01 ± 0.75c | 3.50 ± 0.39bc | 2.60 ± 0.17b |
| 2.30 ± 0.52a | 7.17 ± 0.91ab | 17.56 ± 4.03c | 12.53 ± 2.43bc | 8.72 ± 0.97ab | |
| Cg | 0.90 ± 0.16a | 1.55 ± 0.28ab | 2.71 ± 0.60c | 2.16 ± 0.24bc | 1.41 ± 0.10ab |
| 2.56 ± 0.59a | 4.50 ± 0.97a | 9.37 ± 2.51b | 6.35 ± 0.88ab | 3.87 ± 0.29a | |
| RS | 0.89 ± 0.20a | 1.62 ± 0.31ab | 2.36 ± 0.53b | 1.37 ± 0.25a | 1.23 ± 0.13a |
| 2.06 ± 0.54a | 3.48 ± 0.76a | 6.83 ± 1.57b | 3.25 ± 0.54a | 2.83 ± 0.31a | |
| Septal area | |||||
| LSv | 2.63 ± 0.22a | 5.69 ± 0.77b | 6.25 ± 0.43b | 8.17 ± 0.32c | 7.57 ± 0.30c |
| 7.97 ± 0.81a | 21.05 ± 4.22b | 31.24 ± 3.62c | 40.99 ± 4.31c | 37.81 ± 1.52c | |
| Amygdala | |||||
| CeA | 0.71 ± 0.15a | 2.18 ± 0.27b | 2.80 ± 0.33b | 4.96 ± 0.31c | 4.35 ± 0.73c |
| 2.70 ± 0.72a | 5.94 ± 0.78a | 11.36 ± 2.02ab | 23.73 ± 2.51c | 19.28 ± 4.68bc | |
| MeA | 0.92 ± 0.21a | 2.32 ± 0.02b | 2.37 ± 0.45b | 3.32 ± 0.35c | 2.74 ± 0.30bc |
| 3.85 ± 1.06a | 9.95 ± 0.77b | 13.06 ± 3.03bc | 18.65 ± 2.65c | 13.49 ± 1.81bc | |
| PCoA | 0.46 ± 0.07a | 1.97 ± 0.19b | 2.58 ± 0.26bc | 3.07 ± 0.47c | 2.52 ± 0.14bc |
| 3.02 ± 0.74a | 10.40 ± 0.65b | 18.00 ± 2.65c | 22.01 ± 3.92c | 16.25 ± 0.93bc | |
| Hypothalamus | |||||
| MPO | 1.14 ± 0.24a | 2.09 ± 0.25b | 1.97 ± 0.50ab | 2.87 ± 0.30b | 2.08 ± 0.10b |
| 3.27 ± 0.84a | 6.86 ± 0.78ab | 7.35 ± 2.52ab | 10.78 ± 1.27b | 6.22 ± 0.47a | |
| AH | 1.51 ± 0.34a | 2.62 ± 0.20c | 2.39 ± 0.23bc | 2.18 ± 0.07bc | 1.81 ± 0.14ab |
| 5.32 ± 1.41a | 9.92 ± 0.79bc | 11.12 ± 1.67c | 7.77 ± 0.55ab | 5.71 ± 0.29a | |
| PVN | 1.47 ± 0.32a | 6.70 ± 0.89b | 8.50 ± 0.37b | 7.26 ± 1.10b | 7.89 ± 0.92b |
| 2.59 ± 0.63a | 17.06 ± 1.98b | 27.70 ± 2.87b | 23.87 ± 4.47b | 28.91 ± 5.34b | |
| SON | 0.54 ± 0.10a | 4.67 ± 0.87b | 7.65 ± 1.43b | 7.43 ± 1.47b | 5.82 ± 1.05b |
| 1.30 ± 0.29a | 18.05 ± 5.17ab | 43.60 ± 9.45c | 37.82 ± 10.07bc | 26.59 ± 7.24bc | |
| SCh | 1.13 ± 0.25a | 7.89 ± 0.48c | 6.14 ± 1.31bc | 8.43 ± 1.01c | 4.55 ± 0.62b |
| 3.00 ± 0.78a | 22.59 ± 1.63bc | 20.54 ± 5.59b | 31.90 ± 3.91c | 10.70 ± 1.79a | |
| DMH | 2.08 ± 0.47a | 3.31 ± 0.34b | 3.47 ± 0.42b | 4.37 ± 0.40b | 3.99 ± 0.14b |
| 6.19 ± 1.66a | 13.16 ± 2.58ab | 16.98 ± 3.06b | 19.91 ± 3.44b | 15.19 ± 0.39b | |
| Arc | 1.74 ± 0.43a | 3.28 ± 0.37ab | 4.02 ± 0.46b | 3.84 ± 0.71b | 3.71 ± 0.60b |
| 5.22 ± 1.44a | 11.73 ± 1.25ab | 18.36 ± 2.65b | 17.88 ± 3.90b | 15.28 ± 3.10b | |
| SuM | 1.84 ± 0.41a | 2.96 ± 0.13b | 3.47 ± 0.36bc | 4.48 ± 0.22c | 3.64 ± 0.38bc |
| 6.96 ± 1.78a | 13.91 ± 0.94b | 20.55 ± 3.11bc | 22.04 ± 1.78c | 15.98 ± 1.32bc | |
For each nucleus, the data in the top row represent the number of c-Fos-positive neurons, and the data in the bottom row represent the IOD of c-Fos-positive neurons
Means in a row without a common letter represent significant difference at P < 0.05
AH Anterior hypothalamic area, Arc arcuate hypothalamic nucleus, CeA central amygdaloid nucleus, Cg cingulated cortex, DMH dorsomedial hypothalamic nucleus, LSv ventrolateral septum, MeA medial amygdaloid nucleus, mPFC medial prefrontal cortex, MPO medial preoptic nucleus, PCoA posterior cortical amygdaloid nucleus, PVN hypothalamic paraventricular nucleus, RS retrosplenial cortex, SCh suprachiasmatic nucleus, SON supraoptic nucleus, SuM supramammillary nucleus