Table 1.

Highest and lowest scored parameters in β-adrenergic pathway sensitivity analysis

Model outputs	PKA	GSK3β	ERK	CREB	GATA4
Highest score	$\text{AF}$	$\left[\text{PP}2\text{A}\right]$	${\text{K}}_{\text{Gi}\mathit{\beta }\mathit{\gamma }:\text{PI}3\text{K},\text{iSrc}}$	$\left[{\text{Akt}}_{\text{tot}}\right]$	${\text{K}}_{\text{Gi}\mathit{\beta }\mathit{\gamma }:\text{PI}3\text{K},\text{iSrc}}$
	$\left[\text{AC}\right]$	${\text{K}}_{\text{m},\text{Akt}:\text{PIP}3}$	${\text{K}}_{\text{Ras}-\text{GDP}}$	$\left[{\text{CREB}}_{\text{tot}}\right]$	${\text{K}}_{\text{Ras}-\text{GDP}}$
	${\text{K}}_{\text{act}1,\text{Gs}}$	${\text{K}}_{\text{PP}2\text{A},\text{Akt}:{\text{PI}}_{\text{p}}}$	$\left[\text{Grb}{2}_{\text{tot}}\right]$	${\text{K}}_{\text{PDK}1,\text{Akt}:\text{PIP}3}.\left[\text{PDK}1\right]$	$\left[\text{Grb}{2}_{\text{tot}}\right]$
	$\left[{\text{R}}_{\mathit{\beta }1\text{tot}}\right]$	${\text{Kr}}_{\text{PIP}3,\text{Akt}}$	${\text{K}}_{\text{aSrc},\text{Shc}}$	$\text{AF}$	${\text{K}}_{\text{aSrc},\text{Shc}}$
	$\left[{\text{PKA}}_{\text{tot}}\right]$	${\text{K}}_{\text{hydr},\text{PIP}3}$	${\text{K}}_{\text{m},\text{aSrc}}$	$\left[\text{AC}\right]$	${\text{K}}_{\text{m},\text{aSrc}}$
Lowest score	${\text{h}}_{\text{AC},\text{Gs}}$	$\left[{\text{Akt}}_{\text{tot}}\right]$	$\left[{\text{Akt}}_{\text{tot}}\right]$	${\text{h}}_{\text{AC},\text{Gs}}$	${\text{V}}_{\text{aSrc}}$
	$\left[{\text{PDE}}_{\text{tot}}\right]$	${\text{K}}_{\text{PDK}1,\text{Akt}:\text{PIP}3}.\left[\text{PDK}1\right]$	${\text{V}}_{\text{aSrc}}$	$\left[\text{PP}2\text{A}\right]$	${\text{V}}_{\text{Ras}-\text{GTP}}$
	${\text{K}}_{\text{PDE}}$	${\text{Kf}}_{\text{PIP}3,\text{Akt}}$	${\text{V}}_{\text{Ras}-\text{GTP}}$	${\text{K}}_{\text{m},\text{Akt}:\text{PIP}3}$	${\text{V}}_{{\text{shc}}^{\ast }}$
	${\text{K}}_{\text{hydr},\text{Gs}}$	${\text{K}}_{\text{PI}}$	${\text{V}}_{{\text{shc}}^{\ast }}$	${\text{K}}_{\text{PP}2\text{A},\text{Akt}:{\text{PI}}_{\text{p}}}$	${\text{Kr}}_{{\text{shc}}^{\ast },\text{Grb}2:\text{Sos}}$
	${\text{K}}_{\text{m},\text{Gs}}^{\text{AC}}$	$\left[{\text{PI}}_{\text{tot}}\right]$	${\text{Kr}}_{{\text{shc}}^{\ast },\text{Grb}2:\text{Sos}}$	$\left[{\text{PDE}}_{\text{tot}}\right]$	$\left[{\text{Akt}}_{\text{tot}}\right]$