Fig. 1.

Icilin induced c-fos expression in lamina I and II of the spinal cord dorsal horn. Representative image of the spinal dorsal horn is shown (a). Topical application of icilin leads to increased levels of c-fos protein in the L3–L5 region of the ipsilateral dorsal horn (icilin) as compared to that in the contralateral side (control) (b). Each symbol represents an individual mouse. The horizontal lines indicate the mean values. Scale bar = 100 μm. Compared with the control, ^†p < 0.01. Data are represented as the mean ± SD