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. 2023 Dec 12;14:363. doi: 10.1186/s13287-023-03589-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Surface marker characterisation of BM-MSCs using the standard ISCT panel of markers. A Representative gating strategy for flow cytometric analysis of BM-MSC surface marker expression. B Representative surface marker profile analysis of BM-MSCs at passage 3 for each culture condition. Blue histograms represent each antigen with red overlays representing the corresponding isotype control. C Bar graphs indicate the mean percentage of positive expression for each surface marker. BM-MSCs cultured in all conditions expressed the standard positive surface markers (≥ 90% expression of CD73, CD90, CD105) and lacked expression (≤ 2%) of all negative markers except HLA-DR the expression of which was significantly upregulated in both FBS + FGF2 conditions. Results are presented as the mean ± SD of three biological replicates (n = 3) (****p ≤ 0.0001)