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TRPV2 activation by membrane stretch promotes axon outgrowth in developing sensory and motor neurons. TRPV2 is expressed in both axon shafts and growth cones as shown by red images. The TRPV2 is activated by membrane stretch derived from endogenous axon outgrowth shown by black arrows. The activation of TRPV2 caused high Ca2+ influx and further axon outgrowth
