Table 1.
Summary of TRPV2 function and related disease
| Organ | Cells | Function | Related disease |
|---|---|---|---|
| Brain | Neuron, astrocyte | Synaptic and glial transmission | Depression |
| DRG | Neuron | Nociception | Pain |
| Heart | Myocyte | Myocardial conduction | Cardiac hypertrophy |
| Pancreas | β-Cells | Insulin secretion | Diabetes |
| Intestine | Myenteric neuron | Intestinal motility | Irritable bowel syndrome |
| Spleen | Macrophage, mast cell, lymphocyte | Immune response | Immunodeficiency |
| Urinary bladder | Epithelial cell | Sensing stretch | Bladder cancer |
| Prostate | Epithelial cell | LPC receptor | Prostate cancer |
| Bone | Osteoclast | Calcium oscillation | Cancer |
| Muscle | Skeletal and cardiac muscle cells | Sensing stretch | Muscular dystrophy |
| Blood vessel | Smooth muscle, endothelial cell | Blood pressure control | Cardiomyopathy |