Fig. 2.

Proteasome dysfunction in Rpt3-deficient muscle stem cells impaired their ability to proliferate, survive and differentiate, resulting in defective muscle regeneration. We also found that proteasome inactivation by Rpt3 deficiency in primary myoblasts inhibits cell proliferation and induces apoptosis. Further, proteasome dysfunction conferred by satellite cell-specific Rpt3-knockout induces p53 activation