Fig. 2.

The effects of bilobalide on hippocampal synaptic plasticity. a HFS (arrow 100 Hz, 1 s) induced LTP at SC-CA1 synapses. The black bar shows the timing of the application of bilobalide. The magnitudes of potentiation under the bilobalide conditions did not differ from those seen under the control conditions. Insets Typical waveforms of synaptic responses before (1) and 60 min after (2) the HFS. Scales 0.5 mV, 5 ms. *p < 0.05. b HFS induced LTD under the control conditions at MPP-DG synapses, and bilobalide blocked the induction of LTD. Insets Typical waveforms of synaptic responses before (1) and 60 min after (2) the HFS. Scales 0.5 mV, 5 ms. *p < 0.05