Laser Doppler flow in the left lateral surface of the big toe and lateral surface of the transverse tarsal joint (A-a and b) A typical example of spikes in LDF in the left big toe in the L phase. (B-a) and the number of LDF spikes in the lateral surface of the left big toe (B-b), during mild local cooling of the right foot. Values are presented as the mean ± SE (F phase, n = 6 measurements; L phase, n = 6 measurements). Asterisk indicates a significant difference between the F and L phases, hashtag indicates a significant difference between the resting (rest) and cooling (cool) periods, dagger indicates a significant difference between the rest and recovery periods, all at p < 0.05. Arrows in B-a indicate spikes