Table 3.
Distribution and properties of β-AR subtypes
| SHR | SHR/H | SHR-mtBN | SHR-mtBN/H | |
|---|---|---|---|---|
| β2 (%) | 24.03 ± 0.30 | 31.12 ± 1.42+ | 32.97 ± 2.01* | 31.15 ± 0.42 |
| K iβ2 (nM) | 0.80 ± 0.53 | 1.43 ± 0.17 | 4.80 ± 1.25 | 0.75 ± 0.21 |
| K iβ1 (µM) | 0.73 ± 0.06 | 0.77 ± 0.25 | 0.70 ± 0.07 | 0.31 ± 0.03 |
Data are means (±SEM) of three separate experiments performed in triplicates
β 2 (%) percentage of β2-ARs of total myocardial β-ARs, K i β 2 (β 1) apparent dissociation constant representing the affinity of ICI 118.551 to β2-ARs (β1-ARs)
* p < 0.05 SHR vs. SHR-mtBN; + p < 0.05 SHR vs. SHR/H