Fig. 1.
Effect of nicorandil on INCX1 (modified from [24] with permission). a Chart recording on INCX1. The ramp pulse was initially depolarized from a holding potential of − 60 to +60 mV, then hyperpolarized to − 120 mV, and then depolarized back to − 60 mV at a rate of 680 mV/s. A ramp pulse was given every 10 s. INCX was inhibited completely by KB-R7943, a potent inhibitor of INCX, at 50 μM. b I–V curves on INCX1. c Concentration–response curves of the pinacidil on INCX. d and e Summarized data of L-NAME and ODQ on INCX1. Cont control, Nico nicorandil, KB-R KB-R7943