Table 2.
Assessment of cardiac function in different groups
| Sham | HF | OMT (L) | OMT (M) | OMT (H) | |
|---|---|---|---|---|---|
| Number | 12 | 12 | 12 | 12 | 12 |
| BW (g) | 218.2 ± 12.7 | 227.1 ± 11.1 | 220.5 ± 23.5 | 232.4 ± 17.3 | 236.6 ± 15.4 |
| HW/BW (mg/g) | 2.42 ± 0.27 | 4.39 ± 0.19** | 4.16 ± 0.33 | 3.11 ± 0.28Δ | 3.08 ± 0.15Δ |
| HR (beats/min) | 427 ± 15 | 435 ± 19 | 418 ± 28 | 427 ± 26 | 419 ± 17 |
| LVEDP (mmHg) | 3.9 ± 1.3 | 8.2 ± 1.8** | 7.9 ± 1.2 | 5.1 ± 1.5ΔΔ | 4.6 ± 1.1ΔΔ |
| dp/dt max (mmHg/s) | 4,182.77 ± 209. 53 | 2,462.95 ± 218.13** | 2,783.74 ± 251.12 | 3,794.17 ± 223.59ΔΔ | 3,815.57 ± 205.11ΔΔ |
| dp/dt min (mmHg/s) | −2,892.31 ± 245.17 | −1,554.46 ± 174.68** | −1,668.62 ± 171.53 | −2,515.71 ± 188.43ΔΔ | −2,661.78 ± 202.42ΔΔ |
MI myocardial infarction, BW body weight, HW heart weight, HR heart rate, LVEDP left ventricular end-diastolic pressure, dp/dtmax maximum change in systolic pressure over time, dp/dtmin maximum change in the rate of relaxation over time. Data are presented as mean ± SE 1 mmHg = 0.133 kPa, ** P < 0.01 HF versus sham, * P < 0.05 HF versus sham, ΔΔ P < 0.01 medium-dose, high-dose versus HF, Δ P < 0.05 medium-dose, high-dose versus HF