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. 2022 Oct 26;72:27. doi: 10.1186/s12576-022-00852-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic illustration of the microdialysis technique in the heart in vivo. A dialysis probe is implanted transversely into the lateral wall of the left ventricle. Myocardial interstitial 5-HT and 5-HIAA diffuses into perfusate across the dialysis membrane. Pharmacological agents diffuse into the interstitium according to a concentration gradient by reverse-microdialysis