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. 2022 Oct 26;72:27. doi: 10.1186/s12576-022-00852-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Putative mechanisms regulating cardiac interstitial level of 5-HT in a physiological condition. Interstitial level of 5-HT in the heart is maintained low mostly by fluoxetine-sensitive transporter (SERT) dependent uptake into platelets and stored in intracellular vesicles. This stored 5-HT in the vesicle could be reused and less metabolized. Meanwhile, interstitial 5-HT is also taken up by decynium-22 sensitive transporter (PMAT) into cardiac cells. The transported 5-HT is then metabolized by MAO to produce 5-HIAA