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. 2022 Mar 11;72:7. doi: 10.1186/s12576-022-00829-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Depolarization-induced contractions increased arterial stiffness at low and high stretch pressure when autophagy was deficient in VSMCs. Concentration–response curves of stiffness increase elicited by K⁺ in aortic segments of Atg7^+/+ SM22α-Cre⁺ (+/+) and Atg7^F/F SM22α-Cre⁺ (F/F) mice under physiological pressures (N, 80–120 mmHg, a) and elevated pressures (H, 100–140 mmHg; b) in the presence of L-NAME. E_p in unstimulated conditions (KR, c) and after depolarization with 35 mM K⁺ (d) at normal (N) and high (H) pressure. Two-way ANOVA with pressure and genotype effect indicated and with Sidak’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001 (n = 7)