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. 2022 Jun 20;72:13. doi: 10.1186/s12576-022-00837-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A proposed working model showing Piezo1-mediated suppression of differentiation in brown adipocytes. A Piezo1 agonist (Yoda-1) and endogenous stimuli including mechanical stimuli activate Piezo1, followed by an increase in the [Ca²⁺]_i in pre-adipocytes and the early stage of differentiation in brown adipocytes. Ca²⁺ binds to calmodulin (CaM), and the Ca²⁺/CaM complex activates calcineurin, which suppress the expression of the key transcriptional factors PPARγ and C/EBPα, which in turn suppress the differentiation of brown adipocytes